
GMQ hydrochloride
CAS No. 5361-15-9
GMQ hydrochloride ( NSC 403387 hydrochloride )
产品货号. M22257 CAS No. 5361-15-9
GMQ 盐酸盐是一种有效的选择性酸敏感离子通道 (ASIC) 调节剂。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
10MG | ¥332 | 有现货 |
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25MG | ¥494 | 有现货 |
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50MG | ¥664 | 有现货 |
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100MG | ¥1142 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称GMQ hydrochloride
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述GMQ 盐酸盐是一种有效的选择性酸敏感离子通道 (ASIC) 调节剂。
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产品描述GMQ hydrochloride is a potent and selective acid-sensing ion channel (ASIC) modulator.?It activates ASIC3 channels under neutral pH and blocks acid-induced maximal peak current.Addition of GMQ to pituitary GH3 cells raised the amplitude of Ca2+-activated K+ currents (IK(Ca)), which was reversed by verruculogen or PF1022A, but not by TRAM-39.?Under inside-out current recordings, addition of GMQ into bath enhanced the probability of large-conductance Ca2+-activated K+ (BKCa) channels with an EC50 value of 0.95 M. The activation curve of BKCa channels during exposure to GMQ shifted to a lower depolarized potential, with no change in the gating charge of the curve;?however, there was a reduction of free energy for channel activation in its presence.?As cells were exposed to GMQ, the amplitude of ion currents were suppressed, including delayed rectifying K+ current, voltage-gated Na+ and L-type Ca2+ currents.?In Rolf B1.T olfactory sensory neuron, addition of GMQ was able to induce inward current and to suppress peak INa.?
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体外实验——
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体内实验——
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同义词NSC 403387 hydrochloride
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通路Others
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靶点Other Targets
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受体ion channel (ASIC)
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研究领域——
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适应症——
化学信息
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CAS Number5361-15-9
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分子量237.69
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分子式C10H12ClN5
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纯度>98% (HPLC)
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溶解度In Vitro:?H2O : 3.33 mg/mL (14.01 mM)
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SMILESCC1=NC(NC(N)=N)=NC2=C1C=CC=C2.Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.So, Edmund, Cheung,et al. Multiple regulatory actions of 2-guanidine-4-methylquinazoline (GMQ), an agonist of acid-sensing ion channel type 3, on ionic currents in pituitary GH(3) cells and in olfactory sensory (Rolf B1.T) neurons[J]. Biochemical Pharmacology, 2018.
产品手册




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